Mr Biden was born in Scranton, Pennsylvania – a swing state which Mr Trump won in 2016 – and has touted his ability to win over working class voters who abandoned the Democrats. His first campaign event will be in the state on Monday.
However he must overcome a string of political challenges if he is to win the nomination. The energised progressive Left-wing Democrats, led by Bernie Sanders, are at odds with Mr Biden’s historic willingness to reach across the aisle and work with Republicans.
His moderate politics – including pushing through a hardline crime bill in the 1990s that has blamed for ushering in an era of mass incarceration – will likely face scrutiny.
So too will accusations that he touched women inappropriately at political events, such as rubbing shoulders or kissing people on the head, that have surfaced in recent weeks. He has promised to learn from the incidents.
His age – Mr Biden would be 78 on his first day in office – and status as a white male Washington insider at a time when the party had a historically diverse set of candidates elected to Congress last year will also be questioned.