Lampard introduced substitutes Duane Holmes and Mason Bennett before the hour, and it produced an almost immediate impact.
The goal came from Bennett, a remarkable acrobatic effort as he hooked Malone’s cross over his shoulder to loop the ball over Jones. It was Derby’s first league goal in 420 minutes.
They secured the win 12 minutes from time when Malone turned in Wilson’s miscued shot at the far post. Derby are back in business.
Derby County (4-3-3): Carson; Bogle, Tomori, Keogh, Malone; Johnson, Huddlestone, Wilson (Nugent 89); Waghorn, Marriott (Bennett 57, Jozefzoon (Holmes 57).
Substitutes: Roos (g), Wisdom, Cole, Bird.
Booked: Johnson, Wilson, Tomori, Bennett.
Wigan Athletic (4-3-3): Jones; Byrne, Kipre, Dunkley, Fox (Naismith 33); James, Morsey, L Evans; Massey (Powell 70), Clarke, Jacobs (Windass 78).
Substitutes: O Evans (g), Gibson, Olsson, Garner.
Referee: Tony Harrington (Cleveland)